Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with age
Barbara Arbeithuber, Kate Anthony, Bonnie Higgins, Peter Oppelt, Omar Josef Shebl, Irene Tiemann‐Boege, Francesca Chiaromonte, Thomas Ebner, Kateryna D. Makova
The paper detects mtDNA mutations in oocytes, blood, and saliva across ages and finds mutations increase in blood and saliva but not in oocytes, with age-related differences in mutation frequency distribution.
Science Advances · Aug 6, 2025Peer-reviewedGenomics