Rete Ovarii Epithelial Cells as an Unappreciated Cell of Origin for Pelvic and Ovarian High-Grade Serous Carcinoma
Cheng Wang, Peichao Chen, Xingeng Zhao, Jinpeng Ruan, Xiangmin Lv, Jiyuan Liu, Rui Xu, Kazi Islam, Hongbo Wang, Davie Shi, Madelyn L. Moness, Brianna Carbajal, Gunjan Kumar, Olukemisola A Abioye, Jeniffer McKey, John S. Davis
This study identifies rete ovarii epithelial cells as a new cell of origin for high-grade serous carcinoma, showing their ability to drive malignant transformation and produce tumors with HGSC-like features.
bioRxiv · Oct 31, 2025 · PreprintCancer Biology