PLM-ICE: A Protein Language Model-based Approach for Prediction of Ice nucleating and Antifreeze Proteins
Fawad Ullah, Pawel Pratyush, KC Dukka, Stephen M. Techtmann
PLM-ICE predicts ice-binding proteins with high precision and sensitivity using ESM-2 embeddings and an MLP, outperforming existing methods in multiple metrics.
bioRxiv · Aug 13, 2025 · PreprintBioinformatics