A Computational Model of Levodopa-Induced Toxicity in Substantia Nigra Pars Compacta in Parkinson's Disease
Vignayanandam Ravindernath Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy
The paper develops a multiscale computational model of the SNc-striatum system to study LDOPA-induced toxicity in Parkinson's disease and shows that energy deficiency contributes to neurodegeneration.
bioRxiv · Apr 5, 2020 · PreprintNeuroscience