Mortality Risk-Stratified Septic Serum Depresses Contractility and Mitochondrial Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Andrew J. Lautz, Catherine S. Kapcar, Shuangmin Zhang, Leland Dunwoodie, Kelli Harmon, Christopher N. Mayhew, Mihir R. Atreya, Basilia Zingarelli, Genomics of Pediatric Septic Shock Investigators
The paper exposes human iPSC-derived cardiomyocytes to mortality risk-stratified septic serum, revealing distinct proteomic and transcriptomic changes linked to septic myocardial dysfunction.
bioRxiv · Dec 23, 2025 · PreprintImmunology