Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia
Sarah Bald, Rowan Nelson, Jing Zhang, Markus de Raad, D. Scott, Kendall Hughes, Melisa L. Osborne, Ilija Dukovski, Trent R. Northen, Daniel Segrè
The paper uses consumer-resource models parametrized from monoculture exometabolite data to predict and design synthetic microbial consortia, revealing the importance of cross-feeding interactions and nonlinear dynamics.
bioRxiv · Jan 12, 2026 · PreprintSystems Biology