Preferential CDR masking in paired antibody language models improves binding affinity prediction
Mahtab Talaei, Kenji C. Walker, Boran Hao, Eliot Jolley, Y. Jin, Dima Kozakov, John Misasi, Sándor Vajda, Ioannis Ch. Paschalidis, Diane Joseph‐McCarthy
This paper shows that focusing on complementarity-determining regions (CDRs) in antibody sequences improves binding affinity prediction using region-aware pretraining strategies.
Communications AI & Computing · Aug 13, 2026Peer-reviewedBioinformatics