TP53 status aligns with morphology and metaplastic programs in colorectal cancer organoids, and MDM2 P2 promoter usage reflects p53 activity
Takahiro Tsukui, Kento Shin, Ryoji Yao, Koji Tsuda
This study links TP53 status to morphology and metaplastic programs in CRC organoids, showing P2 promoter usage reflects p53 activity beyond genotype in some cases.
bioRxiv · Sep 29, 2026 · PreprintBioinformatics