Cooperativity through Allee Effects drives growth of diffuse midline gliomas impacting the optimal scheduling of therapeutic interventions
Haider Tari, Ketty Kessler, Elisa Izquierdo, Andrea Sottoriva, Chris Jones
The paper models subclonal interactions in diffuse midline gliomas using a modified Lotka-Volterra model to show how Allee effects influence therapeutic outcomes and treatment scheduling.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology