Modeling rare coding variation on chromosome X provides insight into the genetics and differential sex prevalence of autism spectrum disorder
F. Kyle Satterstrom, Kiana Jodeiry, Behrang Mahjani, Gad Hatem, Se Jun Park, Lambertus Klei, Jack M. Fu, Emilie M. Wigdor, Catalina Betancur, Mark J. Daly, Kathryn Roeder, Bernie Devlin, Joseph D. Buxbaum, David J. Cutler
The paper develops a model to analyze X-linked rare variation in ASD, identifying 9 genes associated with ASD and explaining how X-linked variation could contribute to sex-differential prevalence.
medRxiv · May 7, 2026 · PreprintGenetic & Genomic Medicine