Probing Mechanisms of Allosteric Regulation in AAA+ ATPases for Microtubule Severing and Protein Disaggregation
Maryum Irshad, Krishan Walpalage, Zhaocheng Zhang, Maria Gillen, Ruxandra I. Dima, George Stan
This study investigates allosteric regulation mechanisms in AAA+ ATPases using katanin and ClpB, revealing similar and specific mechanisms through simulations and machine learning.
The Journal of Chemical Physics · Oct 1, 2026Peer-reviewedBiophysics