Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice -- can it explain the behavioral regression in Autism?
Sheng-Nan Qiao, Sung Eun Wang, Kun-Yong Kim, Sungsin Jo, Yong-Hui Jiang
The paper shows that inflammation worsens behavioral issues in mice with partial SHANK3 gene loss, suggesting a mechanism for behavioral regression in human SHANK3-related autism.
Molecular Psychiatry · Mar 25, 2026Peer-reviewedNeuroscience