Determinants of stem cell enrichment in healthy tissues and tumors: implications for non-genetic drug resistance
N. L. Komarova, L. D. Weiss, P. van den Driessche, J. S. Lowengrub, D. Wodarz
This study uses mathematical models to analyze how feedback loops influence cancer stem cell fractions in tumors and healthy tissues, identifying conditions that promote or reduce stem cell enrichment.
bioRxiv · Jun 6, 2019 · PreprintEvolutionary Biology