Unfolding and Translocation of Knotted Proteins by Clp Biological Nanomachines: Synergistic Contribution of Primary Sequence and Topology Revealed by Molecular Dynamics Simulations
H. Y. Y. Fonseka, A. Javidi, L. F. L. Oliveira, C. Micheletti, G. Stan
The paper uses molecular dynamics simulations to study how knotted proteins are unfolded by ClpY ATPase, showing that primary sequence and topology both influence translocation.
bioRxiv · Apr 30, 2021Biophysics