Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate
V. Kriachkov, H. McWilliam, J. Mintern, S. L. Amarasinghe, M. E. Ritchie, L. Furic, D. M. Hatters
The paper investigates how arginine-rich DPRs from C9ORF72 expansions stall ribosomes and shows that this stalling differs from canonical RQC substrates, with no natural regulatory responses.
bioRxiv · Feb 9, 2022Biochemistry