Binding of SARS-CoV-2 non-structured protein 1 to 40S ribosome inhibits mRNA translation
H. Nguyen, L. H. Nguyen, L. S. Mai
The paper uses molecular dynamics simulations to show that SARS-CoV-2 NSP1 increases mRNA binding to 40S ribosomes, inhibiting translation by stabilizing the complex through electrostatic interactions and water molecules.
bioRxiv · Feb 24, 2023 · PreprintBiophysics