Skeletal muscle mitochondrial dysfunction in mice is linked to bone loss via the bone marrow immune microenvironment.
T. JINGWEN, M. Ji Sun, C. Hyo Kyun, L. Ho Yeop, K. Jung Tea, C. Joon Young, K. Seul Gi, R. Dongryeol, C. Xiangguo, C. Je-Yong, T. Masayuki, S. Takayoshi, L. Sang-Hee, S. Minho, Y. Hyon-Seung
This study shows that skeletal muscle mitochondrial dysfunction in mice leads to bone loss by altering the bone marrow immune microenvironment through the CXCL12-CXCR4 axis.
bioRxiv · Dec 9, 2020 · PreprintCell Biology