Multi-scale modeling shows that dielectric differences make NaV channels faster than KV channels
L. Catacuzzeno, L. Sforna, F. Franciolini, R. Eisenberg
The paper uses multi-scale modeling to show that threonine in NaV channels produces stronger dielectric polarization than isoleucine in KV channels, explaining faster activation kinetics.
Journal of General Physiology · Jan 27, 2021Peer-reviewedBiophysics