Are frameworks independent from CDRs in antibodies? Exploring CDR-framework correlation networks of antibodies
Amauri Donadon Leal, Paulo Sergio Lopes de Oliveira, Leandro Oliveira Bortot
This study uses molecular dynamics simulations to show that CDRs significantly influence antibody framework dynamics through CDR-FW correlation networks, highlighting their impact on structure and function.
bioRxiv · Dec 14, 2025 · PreprintImmunology