Author

Leo R. Cooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 1

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:multiple species· 1

Frequent Co-Authors

Hossein AshrafiiD· 1 shared Ján KočíiD· 1 shared Leonid A. VyazoviD· 1 shared Olga Flegontova· 1 shared Pavel FlegontoviD· 1 shared Piya ChangmaiiD· 1 shared Zeynep Şencan· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Hossein AshrafiORCID

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1 paper

Recent·Most cited

Sparse sampling and rare-variant depletion distort PCA visualizations of population structure: recovery with objective-guided manifold learning

Ján Kočí, Olga Flegontova, Piya Changmai, Leonid A. Vyazov, Leo R. Cooper, Hossein Ashrafi, Zeynep Şencan, Pavel Flegontov

Sparse or clustered sampling plus rare-variant filtering collapse PCA plots into triangles and three-ray patterns; objective-guided manifold learning on high-dimensional classic PC scores recovers obscured structure.

bioRxiv · Aug 17, 2026 · PreprintGenetics✦ In-depth digest