Rethinking human AMY1 copy number evolution in light of demographic history
Andrea Soler i Nunez, Cécile Jolly, Camille Humbert, Afifa Chowdhury, Susanne T. Green, Pakou Haréna, Lebarama Bakrobena, Forka Leypey Mathew Fomine, Peter Ebbesen, Zelalem G. Tolesa, Wendawek Abebe Mengesha, Minique H. de Castro, Vinet Coetzee, Himla Soodyall, Leon Mundeke, , Carina M. Schlebusch
This study re-evaluates AMY1 copy number evolution using ancestry-aware models and finds demographic history, not diet, drives global variation.
bioRxiv · Feb 18, 2026 · PreprintEvolutionary Biology