Force loading on molecular clutches governs the stability of cell lamellipodia
Ruihao Xue, Lezi Kang, Yonggang Chen, Haoxiang Yang, Hongyuan Jiang, Ze Gong
This paper develops a mechanochemical model to show that force loading rate and magnitude on adhesion molecules control lamellipodia stability and mechanosensing.
Proceedings of the National Academy of Sciences · May 27, 2026Peer-reviewedBiophysics