Author

Ligong Chen

Tsinghua UniversityPrimary ORCID profile (0000-0002-7893-7173 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Ligong CheniD3 papers · Capital Medical University

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Guo‐Qiang CheniD· 1 shared Haipeng GongiD· 1 shared Jingyu ZhaoiD· 1 shared Nan Xiao· 1 shared Shuyi ZhangiD· 1 shared Tianyu MiiD· 1 shared Wanze Wang· 1 shared Wenbin ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Guo‐Qiang ChenORCID

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1 paper

Recent·Most cited

Accelerating Virtual Directed Evolution of Proteins via Reinforcement Learning

Tianyu Mi, Yuxiang Wang, Jingyu Zhao, Wanze Wang, Yunhao Shen, Nan Xiao, Ligong Chen, Guo‐Qiang Chen, Shuyi Zhang, Wenbin Zhang, Haipeng Gong

This study introduces RelaVDEP, a virtual directed evolution pipeline using reinforcement learning to accelerate protein mutation discovery, showing improved catalytic activity in PETase through novel mutations.

bioRxiv · Jun 25, 2025 · PreprintBioinformatics