Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcome
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle G. Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Gail Petuna Risbridger, Mitchell G. Lawrence, Anna Verena Taubenberger
This study identifies distinct morphomechanical features of prostate cancer-associated fibroblasts (CAFs) linked to patient outcomes and shows these features can be modulated by cancer treatments.
bioRxiv · Mar 21, 2025 · PreprintCancer Biology