Author

Lisa Schmelkin

Temple University

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Evolutionary Biology· 1

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Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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Allan HaldaneiD· 1 shared Jeffrey P. TownsendiD· 1 shared Ronald M. LevyiD· 1 shared Sarah Chung· 1 shared Sudhir KumariD· 1 shared Vincenzo CarnevaleiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperEvolutionary Biology

Allan HaldaneORCID

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1 paper

Recent·Most cited

Entrenchment and contingency in neutral protein evolution with epistasis

Lisa Schmelkin, Vincenzo Carnevale, Allan Haldane, Jeffrey P. Townsend, Sarah Chung, Ronald M. Levy, Sudhir Kumar

The paper shows that protein evolution with epistasis and purifying selection does not lead to entrenchment, and that rate variation is due to epistasis, not historical contingency.

bioRxiv · Jan 9, 2025 · PreprintEvolutionary Biology