Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing
Lois Leenders, Maud A J I van den Oetelaar, Peter E. Engelfriet, Anne‐Marie Buisman, Mary‐lène de Zeeuw‐Brouwer, Lia de Rond, W. M. Monique Verschuren, Roel C.H. Vermeulen, Anton W. Langerak, Pieter Martijn Kolijn
This study examines changes in the B-cell receptor immunoglobulin heavy chain gene repertoire over 30 years of aging, finding reduced diversity and increased clonality after age 60.
Immunity & Ageing · Sep 2, 2026Peer-reviewedImmunology