Therapeutic-induced chromatin remodeling via AP-1/SWI-SNF enhances BK Polyomavirus replication in urothelial cells
Subhajit Chatterjee, Lucy Langenberg, Jason T. Blackard, Stella M. Davies, Benjamin L. Laskin, Gabriel J. Starrett
This study shows that therapeutic agents induce chromatin remodeling via AP-1/SWI-SNF, enhancing BKPyV replication in urothelial cells, and suggests SWI/SNF inhibition as a potential treatment for hemorrhagic cystitis.
bioRxiv · Sep 12, 2026 · PreprintMicrobiology