Nearest-neighbor nonnegative spatial factorization to study spatial and temporal transcriptomics
Priyanka Shrestha, Luis Chumpitaz Diaz, Barbara Elizabeth Engelhardt
The paper introduces NNNSF, a scalable variant of NSF using VNNGPs, reducing computational complexity and improving reconstruction loss on spatial and temporal transcriptomics data.
bioRxiv · Feb 19, 2025 · PreprintBioinformatics