Cryptsim: Modeling the evolutionary dynamics of the progression of Barrett’s esophagus to esophageal adenocarcinoma
Diego Mallo, Rumen Kostadinov, Luis Cisneros, Mary K. Kuhner, Carlo C. Maley
The paper introduces CryptSim, a simulator of crypt evolution in Barrett’s esophagus, showing that interactions between neighboring crypts are crucial in carcinogenesis.
bioRxiv · May 16, 2018 · PreprintCancer Biology