Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
Marc J. Williams, Luiz Zapata, Benjamin Werner, Chris P. Barnes, Andrea Sottoriva, Trevor A. Graham
This study links dN/dS ratios to selective coefficients in somatic evolution, revealing the distribution of fitness effects for mutations in human tissues.
eLife · Mar 30, 2020Peer-reviewedBioinformatics