Lurong Pan

The Metabolic Organ Clock: A Computable Framework Linking Cell-Lineage Architecture to Emergent Organ Bioenergetics

The paper develops a computable framework linking cell-lineage architecture to organ bioenergetics, finding that compartment identity explains most of the variance in metabolic tier.

{Sigma}0-EvoCell: An AI-Native Ontology that Unifies Evolutionary and Cell Biology in Latent Space

The paper introduces ECO, an AI-native ontology that unifies evolutionary and cell biology in latent space, demonstrating its effectiveness in simulating protein evolution, cell cycles, and latent-space alignment.

Correlation Between Information Entropy and Functions of Gene Sequences in the Evolutionary Context: A New Way to Construct Gene Regulatory Networks from Sequence

This paper proposes a framework using information entropy and evolutionary conservation to construct gene regulatory networks from sequence data, demonstrating improved edge discrimination and directionality resolution.

A Systems Framework for Quantifying Programmability and Persistence Across Mammalian Cell Types

The paper introduces a Programmability & Persistence Score to evaluate mammalian cell types based on lifespan, engraftment, and resilience, guiding applications in regenerative medicine and immunotherapy.

Catalytic Efficiency of Conserved Metabolic Enzymes Across Evolutionary Complexity

The paper compares catalytic efficiencies of metabolic enzymes across species, finding pathway-specific and context-dependent patterns rather than a universal trend.