Author

M. J. Fossat

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Biology Disciplines

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Biophysics· 4

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Approach:statistical model· 4 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

R. V. Pappu· 4 shared A. E. Posey· 2 shared X. Zeng· 2 shared A. Chilkoti· 1 shared C. Liu· 1 shared P. Ren· 1 shared

Activity by Year

2020-2023 · peak 2/yr

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6 top collaborators · 11 mutual co-author links

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4 shared papersBiophysics

R. V. Pappu

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4 papers

Recent·Most cited

Uncovering the contributions of charge regulation to the stability of single alpha helices

M. J. Fossat, A. E. Posey, R. V. Pappu

The paper investigates how charge regulation affects the stability of single alpha helices, finding that uncharged glutamate residues and conformational buffering contribute to pH insensitivity.

ChemPhysChem · Jan 4, 2023Peer-reviewedBiophysics

Quantifying charge state heterogeneity for proteins with multiple ionizable residues

M. J. Fossat, A. E. Posey, R. V. Pappu

This paper introduces a q-canonical ensemble framework to analyze potentiometric titration data and determine mesostate pKa values and populations for proteins with multiple ionizable residues.

bioRxiv · Aug 31, 2021Biophysics

Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Sidechains of Amino Acids

M. J. Fossat, X. Zeng, R. V. Pappu

The paper estimates hydration free energies of model compounds mimicking charged amino acid sidechains using TCPD and AMOEBA simulations, revealing structural and thermodynamic differences between acidic and basic residues.

bioRxiv · Feb 4, 2021Biophysics

Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures

X. Zeng, C. Liu, M. J. Fossat, P. Ren, A. Chilkoti, R. V. Pappu

This paper designs intrinsically disordered proteins with LCST phase behavior using Monte Carlo simulations and genetic algorithms.

bioRxiv · Nov 13, 2020Biophysics