Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow
M. J. Morabito, C. Dong, W. Wei, X. F. Zhang, X. Cheng, A. Oztekin, E. Webb
This study uses simulations to show that A2 domain unfolding in vWF multimers under shear flow occurs preferentially near the center of unraveled multimers, with threshold shear rates inversely related to multimer length.
bioRxiv · May 2, 2018Biophysics