BiochemistrybioRxiv
Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by minor groove anchor competition
W. Kobayashi, A. Sappler, D. Bollschweiler…·K. Tachibana
The paper determines the structure of NR5A2 bound to a nucleosome, revealing how it competes with the minor groove anchor to destabilize nucleosomes and facilitate gene expression during reprogramming.
DOI 10.1038/s41594-024-01239-0