Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1
A. Birgy, C. Roussel, H. Kemble, J. Mullaert, K. Panigoni, A. Chapron, J. Chatel, M. Magan, H. Jacquier, S. Cocco, R. Monasson, O. Tenaillon
The paper quantifies epistasis in a β-lactamase α-helix using double mutants and shows it can be explained by a non-linear two-state model.
bioRxiv · Nov 29, 2021Evolutionary Biology