Formation of DNA duplexes in the presence of urea as a chaotropic agent.
Marcello Gottschalk, Robin Jacobi, Sophia Rosencrantz, Ruben R. Rosencrantz, Oleh Fedorych
The paper investigates how urea affects the formation of DNA duplexes with mismatched nucleotides, showing that urea stabilizes these structures through energy level shifts.
bioRxiv · Nov 7, 2025 · PreprintMolecular Biology