Mutant KRAS promotes NF-kB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
Donovan Drouillard, Marissa Davies, Donna M. McAllister, Michael B. Dwinell
This study identifies oncogenic KRAS as a driver of NF-κB-mediated CCL20 chemokine expression in pancreatic ductal adenocarcinoma and shows that targeting CCL20-CCR6 signaling can modulate immune cell recruitment.
bioRxiv · Apr 15, 2026 · PreprintCancer Biology