Structural Evidence for Occupancy-Dependent Inter-Site Coupling in Human Glutathione Synthetase
Matthew Stankus, Mary Anderson
This study uses atomistic simulations to show how ligand binding in one subunit of hGS alters the geometry and solvent environment of the opposite active site, revealing a distributed allosteric network underlying negative cooperativity.
bioRxiv · Jun 10, 2026 · PreprintBiophysics