Buprenorphine Restricts the Conformational Landscape of the μ-Opioid Receptor
Simone Aureli, Maria Bzówka, Nicola Piasentin, Massimo Fuss, Francesco Luigi Gervasio
This study uses simulations to show that buprenorphine restricts the conformational states of the μ-opioid receptor compared to endomorphin-1, affecting signaling bias and efficacy.
bioRxiv · Jun 16, 2026 · PreprintBiophysics