Author

Matthew Bucci

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:large language model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:imputation· 1

Frequent Co-Authors

Aviv RegeviD· 2 shared Hanchen WangiD· 2 shared Linh T. TrinhiD· 2 shared Abbas NaziriD· 1 shared Ana Carolina LeoteiD· 1 shared Avtar SinghiD· 1 shared Bob CheniD· 1 shared Chang Ma· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Aviv RegevORCID

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Author profile →

2 papers

Recent·Most cited

Orion: Towards Lab Automation with Computer-Using Agents

Chang Ma, Linh T. Trinh, Matthew Bucci, Aviv Regev, Hanchen Wang

Orion, an AI agent, automates biomedical image analysis by integrating large language models with software execution and reasoning, generating research reports and hypotheses from imaging data.

bioRxiv · Jun 16, 2026 · PreprintBioinformatics

SpatialAgent: An Autonomous AI Agent for Spatial Biology

Hanchen Wang, Yichun He, Paula Pinto Coelho, Matthew Bucci, Abbas Nazir, Bob Chen, Linh T. Trinh, Serena Zhang, Ziyu Lu, Kexin Huang, Vineethkrishna Chandrasekar, Douglas C. Chung, Minsheng Hao, Ana Carolina Leote, Yong‐Ju Lee, , Aviv Regev

SpatialAgent integrates large language models with dynamic tool retrieval, multimodal interpretation, and claim verification to automate end-to-end spatial biology workflows from gene-panel design to tissue annotation and hypothesis generation.

bioRxiv · Apr 3, 2025 · PreprintBioinformatics