Spatial Clustering of Interface Residues Enhances Few-Shot Prediction of Viral Protein Binding
Maxime Basse, Dianzhuo Wang, Eugene I. Shakhnovich
The paper introduces PROXICLUST, a method that uses spatial clustering of interface residues to predict viral protein binding affinities across larger mutation spaces using smaller datasets.
bioRxiv · Apr 10, 2025 · PreprintMolecular Biology