Serotonin reuptake inhibition rapidly enhances affect-reward coupling and improves mood over time
Regan Mills, Anais Durand, Meggy Croal, Robb B. Rutledge, Liam Mason
This study shows that SSRIs like citalopram enhance affect-reward coupling and improve mood over time by amplifying reward outcomes and prediction errors while reducing negative mood's impact on reward expectations.
bioRxiv · Jul 8, 2026 · PreprintNeuroscience