Optimizing and benchmarking polygenic risk scores with GWAS summary statistics
Zijie Zhao, Tim Gruenloh, Meiyi Yan, Yixuan Wu, Zhongxuan Sun, Jiacheng Miao, Yuchang Wu, Jie Song, Qiongshi Lu
This paper introduces a statistical framework to optimize and benchmark polygenic risk scores using GWAS summary statistics, showing improved performance over existing methods.
Genome biology · Oct 8, 2024Peer-reviewedGenetics