Directed-evolution mutations of adenine base editor ABE8e improve its DNA-binding affinity and protein stability
Haixia Zhu, Xinyi Jiang, Lei Wang, Qin Qin, Menghua Song, Qiang Huang
This study identifies how directed-evolution mutations in ABE8e enhance DNA-binding affinity and protein stability, improving its base editing activity.
bioRxiv · May 9, 2023 · PreprintMolecular Biology