Mathematical Foundations of Beta Diversity: Why Common Metrics Fail in Microbiome Analysis
Zihan Zhu, Yiqian Zhang, Wenhao Li, Michael Greenacre, Satabdi Saha, Yushu Shi, Liangliang Zhang
The paper evaluates common beta diversity metrics in microbiome analysis, identifies their mathematical shortcomings, and introduces a classification framework with tools to improve their validity.
Journal of Statistical Theory and Applications · Feb 17, 2026Peer-reviewedBioinformatics