Generative AI-based design of hybrid transcriptional activator proteins with new DNA-binding specificity
Sota L Okuda, Atsushi Minami, Michio Aiko, Kohei Uetsuka, Kazuteru Miyazaki, Kazumasa Ohtake, Daisuke Kiga
The paper uses a variational autoencoder to generate hybrid transcriptional activators with new DNA-binding specificity, showing functional variants that recognize multiple promoters.
bioRxiv · Mar 13, 2026 · PreprintSynthetic Biology