Hypermutability of ultraconserved histone genes and its contribution to human disease
Zongjin Jiang, Jing Xue, Yingchong Teng, Minhuan Lin, Shaobin Lin, Yi Luo, Xionglei He, Cai Li
The paper identifies high mutation rates in histone genes due to AID/APOBEC enzymes and introduces HistMTR to predict pathogenicity, showing histone mutations contribute to diseases.
bioRxiv · Jun 15, 2026 · PreprintGenomics