Cohort-stratified prioritization of CRISPR-Cas9 sgRNAs for HDR-mediated correction of TP53 hotspot codons in cancer
Sathvik Loke, Neeraj Movva, Mishka Hota
The paper develops a pipeline to prioritize CRISPR-Cas9 sgRNAs for HDR correction of TP53 hotspot mutations in cancer, identifying cohort-specific optimal guides.
bioRxiv · May 22, 2026 · PreprintBioinformatics