Author

Morgan L. Handojo

The University of Texas at Austin

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Biochemistry· 1

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1 Approach:mixed model· 1 Organism:multiple species· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:transformer / foundation model· 1

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Claus O. WilkeiD· 1 shared Luiz Carlos VieiraiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiochemistry

Claus O. WilkeORCID

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Recent·Most cited

Medium-sized protein language models perform well at transfer learning on realistic datasets

Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke

Medium-sized protein language models (e.g. ESM C 600M) with mean embeddings nearly match ESM-2 15B and ESM C 6B in transfer learning on mutational scanning and PISCES data.

Scientific Reports · Jul 1, 2025Peer-reviewedBiochemistry✦ In-depth digest