Interpretable spherical geometry of single-cell state transitions from dominant principal components
Long Yuan, Xuyang Li, My Le, Stephanie C. Hicks, Atul Deshpande, Janis Marie Taube, Alexander S. Szalay
The paper introduces SPHERE-PCA, a method to interpret single-cell state transitions using spherical geometry, revealing structured patterns in developmental and disease datasets.
bioRxiv · Sep 18, 2026 · PreprintSystems Biology